CXCL12 polyclonal, anti-human

Background:
The stromal cell-derived factor 1 (SDF1), also known as C-X-C motif chemokine 12 (CXCL12), is a chemokine protein that in humans is encoded by the CXCL12 gene on chromosome 10. It is ubiquitously expressed in many tissues and cell types. Stromal cell-derived factors 1-alpha and 1-beta are small cytokines that belong to the chemokine family, members of which activate leukocytes and are often induced by proinflammatory stimuli such as lipopolysaccharide, TNF, or IL1. The chemokines are characterized by the presence of 4 conserved cysteines that form 2 disulfide bonds. They can be classified into 2 subfamilies. In the CC subfamily, the cysteine residues are adjacent to each other. In the CXC subfamily, they are separated by an intervening amino acid. The SDF1 proteins belong to the latter group. CXCL12 signaling has been observed in several cancers. The CXCL12 gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.

Alternative Name:
SDF-1, hSDF-1, IRH, hIRH, PBSF, CXCL12, SDF1, SDF1A, SDF1B, 12-O-tetradecanoylphorbol 13-acetate repressed protein 1, AI174028, C-X-C motif chemokine 12, Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1), Chemokine (C-X-C motif) ligand 12, Chemokine CXC motif ligand 12, cxcl12, hIRH, hSDF-1, Intercrine reduced in hepatomas, IRH, OTTHUMP00000019491, PBSF, Pre-B cell growth-stimulating factor, SCYB12, SDF 1, SDF-1, SDF-1-alpha(3-67), SDF-1a, SDF-1b, SDF1, SDF1A, SDF1B, Stromal cell-derived factor 1, Stromal cell-derived factor 1 delta, Stromal cell-derived factor 1 gamma, Stromal cell-derived factor 1a, Stromal cell-derived factor-1 alpha, Thymic lymphoma cell-stimulating factor, Tlsf, TLSF-a, TLSF-b, Tlsfa, Tlsfb, TPAR1,

Application Dilution:
WB:1:500
IHC:1:50-1:200
FC:1:50-1:100

Specificity: CXCL12 polyclonal antibody detects endogenous levels of CXCL12 protein.

Immunogen:
Recombinant protein

MW: 10 kDa

Swiss-Prot: P48061(Human)

Purification & Purity:
Protein affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.