CXXC1 polyclonal, anti-human, mouse, rat

Background:
The human genome contains discrete clusters of unmethylated CpG dinucleotides, called CpG islands, which contribute to the modulation of gene expression by binding transcription factors. Human CpG binding protein (CGBP), detected in K562 cells, is a widely expressed member of CpG binding proteins that requires the CpG dinucleotide to bind DNA. CGBP binds specifically to unmethylated CpG motifs and functions as a transcriptional activator. The CXXC domain of CGBP is conserved in DNA methyltransferase, human trithorax, and methyl-CpG binding protein (MBP), and is involved in DNA-binding. CGBP also contains several domains implicated in protein-protein interactions, such as a coiled-coil domain, and two PHD finger domains, the function of which remains to be determined.

Alternative Name:
CFP 1, CFP1, CpG binding protein, CpG-binding protein, CXXC 1, CXXC finger 1, CXXC finger 1 PHD domain, CXXC finger protein 1, CXXC type zinc finger protein 1, CXXC-type zinc finger protein 1, CXXC1, CXXC1_HUMAN, DNA binding protein with PHD finger and CXXC domain, hCGBP, HsT2645, PCCX 1, PCCX1, PHD finger and CXXC domain containing protein 1, PHD finger and CXXC domain-containing protein 1, PHF 18, PHF18, Protein containing CXXC domain 1, SPP 1, SPP1, ZCGPC 1, ZCGPC1, Zinc finger, CpG binding type containing 1

Application Dilution: WB: 1:500~1:2000, IHC/IF: 1:50~1:200, CHIP: 1:50~1:200

Specificity: CXXC1 polyclonal antibody detects endogenous levels of CXXC1 protein.

Immunogen:
Recombinant full length Human CXXC1.

MW: ~ 76 kDa

Swis Prot.: Q9P0U4

Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.

Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.