CYB5R3 polyclonal, anti-human, mouse, rat

Background:
This gene encodes cytochrome b5 reductase, which includes a membrane-bound form in somatic cells (anchored in the endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. The membrane-bound form exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of fatty acids, in cholesterol biosynthesis, and in drug metabolism. The erythrocyte form is located in a soluble fraction of circulating erythrocytes and is involved in methemoglobin reduction. The membrane-bound form has both membrane-binding and catalytic domains, while the soluble form has only the catalytic domain. Alternate splicing results in multiple transcript variants. Mutations in this gene cause methemoglobinemias.

Synonyms: B5R, DIA1

Cellular Location: Cytoplasm Cytoplasmic side Endoplasmic reticulum membrane Lipid-anchor Mitochondrion outer membrane

Immunogen:
Recombinant protein of human CYB5R3

Gene Symbol: CYB5R3

Gene ID: 1727

Swiss prot: P00387

Calculated MW: 34kDa

Recommended dilution:
WB 1:500-2000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.