Cyclin A2 Polyclonal Antibody

Background:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions.

Research Area: Cancer, Cell Biology, Cardiovascular, Epigenetics and Nuclear Signaling

Synonyms:
CCN1, CCNA, Cyclin A2, CCNA2, cyclin-A2

Immunogen: A synthetic peptide of human Cyclin A2

Swissprot: P20248
Gene ID: 890

Calculated MW: 48 kDa
Observed MW: 55 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Citation(s):
https://www.mdpi.com/1420-3049/24/1/121