Cyclin D1 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Cyclin D1, also known as CCND1, is a human gene. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1-S phase of the cell cycle. Amplification or overexpression of cyclin D1 plays pivotal roles in the development of a subset of human cancers including parathyroid adenoma, breast cancer, colon cancer, lymphoma, melanoma, and prostate cancer. The cyclin D1 gene is overexpressed in human breast cancers and is required for oncogene-induced tumorigenesis. Brisken et al.(2003) found that prolactin(PRL; 176760) induced IGF2(147470) mRNA and IGF2 induced cyclin D1 protein expression in mouse mammary epithelial cultures. And they also concluded that IGF2 is a mediator of prolactin-induced alveologenesis and that prolactin, IGF2, and cyclin D1 are components of a developmental pathway in mammary gland.

Description:
Rabbit IgG polyclonal antibody for G1/S-specific cyclin-D1 (CCND1) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
AI327039 antibody, B cell ccl/lymphoma 1 antibody, B cell CLL/lymphoma 1 antibody, B cell leukemia 1 antibody, B-cell leukemia 1 antibody, B cell lymphoma 1 protein antibody, B-cell lymphoma 1 protein antibody, BCL 1 antibody, BCL-1 antibody, BCL-1 oncogene antibody, BCL1 antibody, BCL1 oncogene antibody, CCND 1 antibody, CCND1 antibody, CCND1 protein antibody, CCND1/FSTL3 fusion gene, included antibody, CCND1/IGHG1 fusion gene antibody, CCND1/IGHG1 fusion gene, included antibody, CCND1/IGLC1 fusion gene, included antibody, CCND1/PTH fusion gene, included antibody, CCND1_HUMAN antibody, cD1 antibody, Cyl 1 antibody, D11S287E antibody, G1/S specific cyclin D1 antibody, G1/S-specific cyclin-D1 antibody, Parathyroid adenomatosis 1 antibody, PRAD1 antibody, PRAD1 oncogene antibody, U21B31 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of mouse Cyclin D1(219-238aa SPNNFLSCYRTTHFLSRVIK), identical to the related rat sequence, and different from the related human sequence by three amino acids.A synthetic peptide corresponding to a sequence at the C-terminus of mouse Cyclin D1(219-238aa SPNNFLSCYRTTHFLSRVIK), identical to the related rat sequence, and different from the related human sequence by three amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.