Cyclin D1 Polyclonal Antibody

Background:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

Research Area: Cancer, Cell Biology, Epigenetics and Nuclear Signaling

Synonyms:
BCL1, D11S287E, PRAD1, U21B31, CCND1, Cyclin D1, cyclin D1

Immunogen: A synthetic peptide of human Cyclin D1 (NP_444284.1).

Swissprot: P24385
Gene ID: 595

Calculated MW: 33 kDa
Observed MW: 37 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Citation(s):
https://pubmed.ncbi.nlm.nih.gov/32251713/