Cyclin D2 (clone 6E11-G6-F5), anti-human

Background:
The protein encoded by this gene belongs to the highly conserved cyclin family,whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle.Cyclins function as regulators of CDK kinases.Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event.This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition.This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb.Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation.High level expression of this gene was observed in ovarian and testicular tumors.[provided by RefSeq,Oct 2008]

Synonyms: KIAK0002, MPPH3

Cellular Location: Cytoplasm Membrane Nucleus

Immunogen:
Purified recombinant human Cyclin D2 protein fragments expressed in E.coli.

Gene Symbol: Cyclin D2

Gene ID: 894

Swiss prot: P30279

Calculated MW: 38kDa

Recommended dilution:
WB 1:1000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.