Cyclin D2 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS7404
Background:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors.
Alternative Name:
CCND 2, CCND2, CCND2_HUMAN, CyclinD2, G1/S specific cyclin D2, G1/S-specific cyclin-D2, KIAK0002, MGC102758,
Application Dilution: WB: 1:500~1:2000, IHC/IF: 1:50~1:200
Specificity: Cyclin D2 polyclonal antibody detects endogenous levels of Cyclin D2 protein.
Immunogen:
Recombinant full length Human CCND2.
MW: ~33 kDa
Swis Prot.: P30279
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors.
Alternative Name:
CCND 2, CCND2, CCND2_HUMAN, CyclinD2, G1/S specific cyclin D2, G1/S-specific cyclin-D2, KIAK0002, MGC102758,
Application Dilution: WB: 1:500~1:2000, IHC/IF: 1:50~1:200
Specificity: Cyclin D2 polyclonal antibody detects endogenous levels of Cyclin D2 protein.
Immunogen:
Recombinant full length Human CCND2.
MW: ~33 kDa
Swis Prot.: P30279
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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