Cyclin E1 (phospho-Thr77) polyclonal, anti-human, mouse antibody
€355.00
In stock
SKU
AC-ABV11848-100
Catalog Number: AC-ABV11848-100
Size: 100 µl
Host: Rabbit IgG
Applications: WB, IHC, IF, ICC
Datasheet
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Size: 100 µl
Host: Rabbit IgG
Applications: WB, IHC, IF, ICC
Datasheet
Request Information
Background:
Cyclin E1 is a regulatory subunit of the CDK2 kinase. It is central for the regulation of the G1/S transition and its abundance is tightly regulated throughout the cell cycle via ubiquitination. Cyclin E has been the subject of intense study in relation to tumorigenesis and cancer management and prognosis. Multiple isoforms of Cyclin E are only expressed in tumors but not in normal tissue, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in the Cyclin E protein have been implicated as indicators of worse prognosis in various cancers.
Other Names:
CCNE, G1/S-specific cyclin-E1
Primary Accession: P24864
Gene Name: CCNE1
Gene ID: 898
Cyclin E1 is a regulatory subunit of the CDK2 kinase. It is central for the regulation of the G1/S transition and its abundance is tightly regulated throughout the cell cycle via ubiquitination. Cyclin E has been the subject of intense study in relation to tumorigenesis and cancer management and prognosis. Multiple isoforms of Cyclin E are only expressed in tumors but not in normal tissue, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in the Cyclin E protein have been implicated as indicators of worse prognosis in various cancers.
Other Names:
CCNE, G1/S-specific cyclin-E1
Primary Accession: P24864
Gene Name: CCNE1
Gene ID: 898
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