CYFIP2 Polyclonal Antibody
€0.00
In stock
SKU
ELK-ES8500
Catalog Number: ELK-ES8500
Reactivity: Human, Mouse, Rat
Applications: WB, ELISA
Information
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Reactivity: Human, Mouse, Rat
Applications: WB, ELISA
Information
Request Manual ELK-
Questions? Contact us!
Background:
disease:Up-regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis (at protein level).,function:Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA.,induction:By p53.,RNA editing:Partially edited. Editing appears to be brain-specific.,similarity:Belongs to the CYFIP family.,subcellular location:Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus.,subunit:Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1.,
Alternative Names:
Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121)
Immunogen: Synthesized peptide derived from CYFIP2 at AA range: 1171-1220
Isotype: Rabbit
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/ml
Observed band: 150+45
GeneID: CYFIP2
Storage: -20°C/1 year
NOTE: For Research Use Only
disease:Up-regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis (at protein level).,function:Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA.,induction:By p53.,RNA editing:Partially edited. Editing appears to be brain-specific.,similarity:Belongs to the CYFIP family.,subcellular location:Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus.,subunit:Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1.,
Alternative Names:
Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121)
Immunogen: Synthesized peptide derived from CYFIP2 at AA range: 1171-1220
Isotype: Rabbit
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/ml
Observed band: 150+45
GeneID: CYFIP2
Storage: -20°C/1 year
NOTE: For Research Use Only
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