CYP11A1 Polyclonal Antibody

Background:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide.

Research Area: Cancer, Cardiovascular, Metabolism, Signal Transduction

Synonyms:
CYP11A1, CYP11A, CYPXIA1, P450SCC

Immunogen: Recombinant fusion protein of human CYP11A1 (NP_000772.2).

Swissprot: P05108
Gene ID: 1583

Calculated MW: 42 kDa/60 kDa
Observed MW: 50 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:20-1:50 IF 1:20-1:50"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.