CYP11B1 polyclonal, anti-human

Quantity: 100 µg

Background:
CYP11B1(Cytochrome p450, family 11, subfamily B, polypeptide 1), also called Steroid 11-beta-hydroxylase or P450C11, is a steroid hydroxylase found in the zona fasciculata. The CYP11B1 gene functions primarily in mitochondria in the zona fasciculata of the adrenal cortex to convert 11-deoxycortisol to cortisol and 11-deoxycorticosterone to corticosterone. CYP11B1 is a member of the cytochrome P450 superfamily of enzymes. It is mapped on 8q24.3. The CYP11B1 gene contains 9 exons and spans 6.5 kb. Using RT-PCR, Kayes-Wandover and White detected CYP11B1 mRNA in human cardiac tissue samples from left and right atria, aorta, apex, intraventricular septum, and atrioventricular node, as well as whole adult and fetal heart. Ventricles did not express CYP11B1. In patients with 11-beta-hydroxylase deficiency leading to hypertension and congenital adrenal hyperplasia, Pascoe et al. identified mutations in the CYP11B1 gene.

Description:
Rabbit IgG polyclonal antibody for Cytochrome P450 11B1, mitochondrial (CYP11B1) detection. Tested with WB in Human.

Synonyms:
CPN1 antibody, CYP11B antibody, CYPXIB1 antibody, Cytochrome P 450c11 antibody, Cytochrome P450 11B1, mitochondrial antibody, Cytochrome p450 XIB1 antibody, Cytochrome P450, family 11, subfamily B, polypeptide 1 antibody, Cytochrome P450, subfamily XIB(steroid 11 beta hydroxylase), polypeptide 1 antibody, Cytochrome P450C11 antibody, FHI antibody, P 450C11 antibody, P450C11 antibody, S11BH antibody, Steroid 11 beta hydroxylase antibody, Steroid 11 beta monooxygenase antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human CYP11B1(436-450aa RNFYHVPFGFGMRQC).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.