CYP11B2 Polyclonal Antibody

Background:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency.

Research Area: Cancer, Cardiovascular, Metabolism

Synonyms:
ALDOS, Aldosterone synthase, Aldosterone-synthesizing enzyme, C11B2, CYP11B2, CYPXIB2, Cytochrome P-450Aldo, Cytochrome P-450C18, Cytochrome P450 11B2, Cytochrome P450 11B2, mitochondrial, mitochondrial, P-450Aldo, P-450C18, Steroid 18-hydroxylase

Immunogen: Synthetic peptide of human CYP11B2

Swissprot: P19099
Gene Accession: NP000489

Calculated MW: 58 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-1:300, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.