CYP1A1 polyclonal, anti-human, mouse, rat

Background:
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Synonyms: AHH, AHRR, CP11, CYP1, CYPIA1, P1-450, P450-C, P450DX

Cellular Location: Endoplasmic reticulum membrane Microsome membrane Peripheral membrane protein

Immunogen:
Recombinant protein of human CYP1A1

Gene Symbol: CYP1A1

Gene ID: 1543

Swiss prot: P04798

Calculated MW: 58kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.