CYP1A2 polyclonal, anti-human

Protein Family: Cytochrome P450; Enzymes

Pathway and Disease: Amino Acid Metabolism; Cancers; Cofactor and Vitamin Metabolism; Lipid Metabolism

Description:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, cytochrome P450 1A2 (CYP1A2) is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. CYP1A2 is most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by CYP1A2 in the liver through an initial N3-demethylation. It also acts in the metabolism of aflatoxin B1 and acetaminophen. CYP1A2 participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. It catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.

Alternate Names: CYP1A2, Cytochrome P450 1A2, CYPIA2, cytochrome P(3)450, P450-P3

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P05177

Antigen: Human recombinant CYP1A2

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.