CYP1A2 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
CYP1A2 (Cytochrome P450, Subfamily I, Polypeptide 2) is a member of the cytochrome P450 mixed-function oxidase system and is involved in the metabolism of xenobiotics in the body. CYP1A2 is a member of the cytochrome P450 superfamily of enzymes. In humans, the CYP1A2 enzyme is encoded by the CYP1A2 gene. CYP1A2 localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The CYP1A2 gene encodes a P450 enzyme involved in O-deethylation of phenacetin. Ikeya et al. (1989) found that the human CYP1A2 gene spans almost 7.8 kb and contains 7 exons. The CYP1A2 gene is mapped on 15q24.1. CYP1A2 accounts for nearly 15% of the cytochrome P450 in the human liver. CYP1A2 displays higher activity in men than in women, and is inhibited by oral contraceptives. Inducers of CYP1A2 include cruciferous vegetables. Cigarette smoking has also been shown to increase CYP1A2 activity. Expression of CYP1A2 appears to be induced by various dietary constituents.

Description:
Rabbit IgG polyclonal antibody for Cytochrome P450 1A2 (CYP1A2) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
Aryl hydrocarbon hydroxylase antibody, CP 12 antibody, CP12 antibody, CP1A2_HUMAN antibody, CYP1A2 antibody, CYPIA2 antibody, Cytochrome P(3)450 antibody, Cytochrome P450 1A2 antibody, Cytochrome P450 4 antibody, Cytochrome P450 family 1 polypeptide 2 antibody, Cytochrome P450 family 1 subfamily A polypeptide 2 antibody, Cytochrome P450 subfamily I aromatic compound inducible polypeptide 2 antibody, Cytochrome P450-P3 antibody, Cytochrome P4501A2 antibody, Dioxin inducable P3 450 antibody, Flavoprotein linked monooxygenase antibody, Microsomal monooxygenase antibody, P(3)450 antibody, P3 450 antibody, P450 4 antibody, P450 form 4 antibody, P450 P3 antibody, P450(PA) antibody, Xenobiotic monooxygenase antibody.

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human CYP1A2 recombinant protein (Position: H185-D320). Human CYP1A2 shares 69.9% and 72.1% amino acid (aa) sequence identity with mouse and rat CYP1A2, respectively.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.