CYP27A1 Polyclonal Antibody

Background:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein oxidizes cholesterol intermediates as part of the bile synthesis pathway. Since the conversion of cholesterol to bile acids is the major route for removing cholesterol from the body, this protein is important for overall cholesterol homeostasis. Mutations in this gene cause cerebrotendinous xanthomatosis, a rare autosomal recessive lipid storage disease.

Research Area: Cancer, Cardiovascular, Metabolism, Signal Transduction

Synonyms:
12-alpha-triol 27-hydroxylase, 5-beta-cholestane-3-alpha, 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 26-hydroxylase, 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 27-hydroxylase, 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 27-hydroxylase, 7-alpha, Cholestanetriol 26 monooxygenase, CP27, CP27A, CTX, CYP, CYP27, CYP27A1, Cytochrome P 450C27/25, Cytochrome P-450C27/25, Cytochrome P450 27, Cytochrome P450 27 mitochondrial, Cytochrome P450 family 27 subfamily A member 1, Cytochrome P450 family 27 subfamily A polypeptide 1, Cytochrome P450 subfamily XXVIIA (steroid 27-hydroxylase cerebrotendinous xanthomatosis) polypeptide 1, mitochondrial, Sterol 26 hydroxylase, Sterol 26 hydroxylase mitochondrial, Sterol 26-hydroxylase, Sterol 27 hydroxylase, Sterol 27-hydroxylase, Vitamin D(3) 25 hydroxylase, Vitamin D(3) 25-hydroxylase

Immunogen: Recombinant protein of human CYP27A1

Swissprot: Q02318
Gene Accession: BC051851

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.6 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-14836/sc-14835