CYP2C9 Polyclonal Antibody

Background:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.

Research Area: Cancer, Cardiovascular, Metabolism, Signal Transduction

Synonyms:
CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9

Immunogen: Recombinant fusion protein of human CYP2C9 (NP_000762.2).

Swissprot: P11712
Gene ID: 1559

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "IHC 1:50-1:200 IF 1:10-1:100"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.