CYP2E1 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Cytochrome P450 2E1 (abbreviated CYP2E1), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body. In humans, the CYP2E1 enzyme is encoded by the CYP2E1 gene. It is mapped to 10q26.3. While it is involved in the oxidative metabolism of a small range of substrates (mostly small polar molecules), there are many important drug interactions mediated by CYP2E1. Most drugs undergo deactivation by CYP2E1, either directly or by facilitated excretion from the body. Also, many substances are bioactivated by CYP2E1 to form their active compounds. In addition, CYP2E1 is an important enzyme for the conversion of ethanol to acetaldehyde and to acetate in humans. In the conversion sequence of acetyl-CoA to glucose, CYP2E1 transforms acetone via acetol into propylene glycol and methylglyoxal, the precursors of pyruvate, acetate and lactate.

Description:
Rabbit IgG polyclonal antibody for Cytochrome P450 2E1 (CYP2E1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
4-nitrophenol 2-hydroxylase antibody, CP2E1_HUMAN antibody, CPE 1 antibody, CPE1 antibody, CYP2E antibody, CYP2E1 antibody, CYPIIE1 antibody, Cytochrome P450 2E1 antibody, cytochrome P450 family 2 subfamily E polypeptide 1 antibody, Cytochrome P450 isozyme 3A antibody, Cytochrome P450 LM3A antibody, Cytochrome P450 subfamily IIE (ethanol inducible) polypeptide 1 antibody, Cytochrome P450, family 2, subfamily e, polypeptide 1 antibody, cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1 antibody, Cytochrome P450, subfamily IIE antibody, Cytochrome P450-ALC antibody, Cytochrome P450-J antibody, Cytochrome P450RLM6 antibody, EC 1.14.13.- antibody, EC 1.14.13.n7 antibody, Ethanol inducible p450 antibody, Ethanol-inducible P450 antibody, flavoprotein-linked monooxygenase antibody, MGC133529 antibody, microsomal monooxygenase antibody, OTTHUMP00000020813 antibody, OTTHUMP00000046571 antibody, P450 ALC antibody, P450 J antibody, P450-J antibody, P450C2E antibody, P450J antibody, P450RLM6 antibody, xenobiotic monooxygenase antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human CYP2E1 recombinant protein (Position: M1-Y310). Human CYP2E1 shares 73% and 74% amino acid (aa) sequences identity with mouse and rat CYP2E1, respectively.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.