CYP2E1 Polyclonal Antibody

Background:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.

Research Area: Cancer, Cardiovascular, Metabolism, Signal Transduction

Synonyms:
4-nitrophenol 2-hydroxylase, CP2E1, CPE1, CYP2E, Cyp2e1, CYPIIE1, Cytochrome P450 2E1, Cytochrome P450 isozyme 3A, Cytochrome P450 LM3A, Cytochrome P450, family 2, subfamily e, polypeptide 1, cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1, Cytochrome P450, subfamily IIE, Cytochrome P450-ALC, Cytochrome P450-J, Cytochrome P450RLM6, EC 1.14.13.-, EC 1.14.13.n7, Ethanol-inducible P450, Flavoprotein-linked monooxygenase, MGC133529, Microsomal monooxygenase, OTTHUMP00000020813, OTTHUMP00000046571, P450 ALC, P450-J, P450C2E, P450J, P450RLM6, Xenobiotic monooxygenase

Immunogen: Recombinant protein of human CYP2E1

Swissprot: P05181
Gene Accession: BC067435

Calculated MW: 57 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.5 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-133491