CYP2E1 Polyclonal Antibody

Background:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.

Research Area: Cancer, Cardiovascular, Metabolism, Signal Transduction

Synonyms:
CYP2E1, CPE1, CYP2E, P450-J, P450C2E

Immunogen: Recombinant fusion protein of human CYP2E1 (NP_000764.1).

Swissprot: P05181
Gene ID: 1571

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "IHC 1:50-1:100 IF 1:20-1:100"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.