CYP46 polyclonal, anti-human, mouse

Background:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.

Synonyms: CYP46A1, CP46, CYP46, cholesterol 24-hydroxylase

Cellular Location: Nucleus Cytoplasm Cell membrane

Immunogen:
A synthetic peptide of human CYP46

Gene Symbol: CYP46

Gene ID: 10858

Swiss prot: Q9Y6A2

Calculated MW: 57/46/38kDa

Recommended dilution:
IHC 1:50-200

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.