CYP46A1 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP8726a
Background:
CYP46A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.
Other Names:
Cholesterol 24-hydroxylase, CH24H, Cytochrome P450 46A1, CYP46A1, CYP46
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP8726a was selected from the N-term region of human CYP46A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: CYP46A1 {ECO:0000303|PubMed:20667828, ECO:0000312|HGNC:HGNC:2641}
Gene ID: 10858
Primary Accession: Q9Y6A2
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
CYP46A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.
Other Names:
Cholesterol 24-hydroxylase, CH24H, Cytochrome P450 46A1, CYP46A1, CYP46
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP8726a was selected from the N-term region of human CYP46A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: CYP46A1 {ECO:0000303|PubMed:20667828, ECO:0000312|HGNC:HGNC:2641}
Gene ID: 10858
Primary Accession: Q9Y6A2
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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