CYP46A1 polyclonal, anti-human, mouse, rat

Background:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.

Synonyms: CP46, CYP46

Cellular Location: Endoplasmic reticulum membrane Microsome membrane Single-pass membrane protein

Immunogen:
Recombinant protein of human CYP46A1

Gene Symbol: CYP46A1

Gene ID: 10858

Swiss prot: Q9Y6A2

Calculated MW: 57kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.