CYP8A1 polyclonal (C-term), anti-human
€0.00
In stock
SKU
AC-AP7997B
Catalog Number: AC-AP7997B
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB17094
Applications: WB, IHC-P
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB17094
Applications: WB, IHC-P
Datasheet
Request Information
Background:
CYP8A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.
Other Names:
Prostacyclin synthase, Prostaglandin I2 synthase, PTGIS, CYP8, CYP8A1
Target/Specificity:
This CYP8A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 472-500 amino acids from the C-terminal region of human CYP8A1.
Antigen Region:
472-500
Antigen Type: Synthetic Peptide
Gene Name: PTGIS
Gene ID: 5740
Primary Accession: Q16647
NCBI Accession: NP_000952.1
Other Accession: Q29626
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
CYP8A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.
Other Names:
Prostacyclin synthase, Prostaglandin I2 synthase, PTGIS, CYP8, CYP8A1
Target/Specificity:
This CYP8A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 472-500 amino acids from the C-terminal region of human CYP8A1.
Antigen Region:
472-500
Antigen Type: Synthetic Peptide
Gene Name: PTGIS
Gene ID: 5740
Primary Accession: Q16647
NCBI Accession: NP_000952.1
Other Accession: Q29626
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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