Cystatin C polyclonal, anti-human

Quantity: 100 µg

Background:
Cystatin C or cystatin 3, a protein encoded by the CST3 gene, is mainly used as a biomarker of kidney function. Recently, it has been studied for its role in predicting new-onset or deteriorating cardiovascular disease. It also seems to play a role in brain disorders involving amyloid, such as Alzheimer's disease. By human-rodent somatic cell hybridizations, Abrahamson et al.(1989) mapped the human CST3 to chromosome 20. Cystatin C was originally described as a constituent of normal cerebrospinal fluid(CSF) and of urine from patients with renal failure(Grubb and Lofberg, 1982). It is present in a number of neuroendocrine cells and its concentration in the CSF was reported to be 5.5 times that in plasma of healthy adults(Lofberg and Grubb, 1979; Lofberg et al., 1981; Lofberg et al., 1983). Grubb and Lofberg(1982) detected the protein in human pituitary gland, and suggested that it is part of the gastroenteropancreatic neuroendocrine system.

Description:
Rabbit IgG polyclonal antibody for Cystatin-C (CST3) detection. Tested with WB, IHC-P, ICC in Human.

Synonyms:
AD 8 antibody, AD8 antibody, Amyloid angiopathy and cerebral hemorrhage antibody, ARMD11 antibody, bA218C14.4(cystatin C) antibody, bA218C14.4 antibody, Cst 3 antibody, Cst3 antibody, CST3 protein antibody, Cystatin 3 antibody, Cystatin-3 antibody, Cystatin-C antibody, Cystatin3 antibody, CystatinC antibody, CYTC_HUMAN antibody, Gamma trace antibody, Gamma-trace antibody, HCCAA antibody, MGC117328 antibody, Neuroendocrine basic polypeptide antibody, Post gamma globulin antibody, Post-gamma-globulin antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human Cystatin C(45-63aa EEEGVRRALDFAVGEYNKA).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P, ICC

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.