Cytokeratin 1 polyclonal, anti-human, mouse, rat

Background:
Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins constitute up to 85% of a mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization, and they function to maintain the overall structural integrity of epithelial cells. The alpha-helical coiled-coil dimers associate laterally end-to-end to form 10-nm diameter filaments. Cytokeratins are useful markers of tissue differentiation, and they aid in the characterization of malignant tumors. Cytokeratin 1 is highly expressed in several malignancies including epithelioid hemangioendohtheliomas, angiosarcomas, schwannomas, epithelioid sarcomas and synodal sarcomas. The gene encoding human Cytokeratin 1 maps to chromosome 12q13.13. Mutations in the gene encoding human Cytokeratin 1 lead to abnormal filament associations and epidermolytic hyperkeratosis.

Alternative Name:
CK-1, K1, KRT1, 67 kDa cytokeratin, CK-1, CK1, Cytokeratin-1, Cytokeratin1, EHK, EHK1, Epidermolytic hyperkeratosis 1, EPPK, Hair alpha protein, K1, K2C1, Keratin, Keratin type II cytoskeletal 1, Keratin-1, Keratin1, KRT 1, Krt1, KRT1A, NEPPK, type II cytoskeletal 1, Type II keratin Kb1, Type-II keratin Kb1,

Application Dilution:
WB:1:1,000
IHC:1:100-1:500

Specificity: Cytokeratin 1 polyclonal antibody detects endogenous levels of Cytokeratin 1 protein.

Immunogen:
recombinant protein

MW: 72 kDa

Swiss-Prot: P04264(Human) P04104(Mouse) Q6IMF3(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.