Cytokeratin 14 polyclonal, anti-human, mouse, rat

Background:
Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed in pairs in both keratinized and non-keratinized epithelial tissue, where they constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. The a-helical coiled-coil dimers associate laterally end-to-end to form 10 nm diameter filaments. Cytokeratins are useful markers of tissue differentiation and, in addition, they aid in the characterization of malignant tumors. In Bowen’s disease, the characteristic malignancy of the epidermis exhibits distinct expression patterns of Cytokeratin 14. The gene encoding human Cytokeratin 14 maps to chromosome 17q12-21. Mutations in this gene lead to epidermolysis bullosa simplex, an inheritied skin disorder characterized by skin blistering due to basal keratinocyte fragility.

Alternative Name:
CK-14, K14, KRT14, CK 14, CK-14, ck14, Cytokeratin 14, Cytokeratin-14, Cytokeratin14, Dowling Meara, EBS3, EBS4, Epidermolysis bullosa simplex, K14, K1C14, Keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner), Keratin 14, Keratin, Keratin type I cytoskeletal 14, Keratin, type I cytoskeletal 14, Keratin-14, Keratin14, Koebner, Krt 14, Krt14, NFJ, OTTHUMP00000164624, type I cytoskeletal 14,

Application Dilution:
WB:1:1,000-1:2,000
ICC:1:100-1:500
IHC:1:100-1:500

Specificity: Cytokeratin 14 polyclonal antibody detects endogenous levels of Cytokeratin 14 protein.

Immunogen:
recombinant protein

MW: 53 kDa

Swiss-Prot: P02533(Human) Q61781(Mouse) Q6IFV1(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.