Cytokeratin 15 (clone ), anti-human, mouse
€428.00
In stock
SKU
BS9947M
Background:
Cytokeratin 15 is an intermediate filament (IF) type I protein that is responsible for the mechanical integrity of epithelial cells. Keratin family members are subdivided into cytokeratins and hair keratins. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceus. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a diagnosis difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins.
Alternative Name:
Keratin, type I cytoskeletal 15, Cytokeratin-15, Short name=CK-15, Keratin-15, Short name=K15, KRT15, KRTB, Keratin 15, CK15, CK 15, Keratin15
Application Dilution: WB: 1:1000-1:2000, IHC/IF: 1:50-1:200, FC: 1:50-1:100
Specificity: This antibody detects endogenous levels of Cytokeratin 15 and does not cross-react with related proteins.
Immunogen:
Recombinant antibody.
MW: ~ 49 kDa
Swis Prot.: P19012
Purification & Purity:
Protein A affinity purified
Format:
Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Cytokeratin 15 is an intermediate filament (IF) type I protein that is responsible for the mechanical integrity of epithelial cells. Keratin family members are subdivided into cytokeratins and hair keratins. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceus. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a diagnosis difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins.
Alternative Name:
Keratin, type I cytoskeletal 15, Cytokeratin-15, Short name=CK-15, Keratin-15, Short name=K15, KRT15, KRTB, Keratin 15, CK15, CK 15, Keratin15
Application Dilution: WB: 1:1000-1:2000, IHC/IF: 1:50-1:200, FC: 1:50-1:100
Specificity: This antibody detects endogenous levels of Cytokeratin 15 and does not cross-react with related proteins.
Immunogen:
Recombinant antibody.
MW: ~ 49 kDa
Swis Prot.: P19012
Purification & Purity:
Protein A affinity purified
Format:
Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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