Cytokeratin 16 polyclonal, anti-human

Background:
Cytokeratins comprise a diverse group of intermediate filament proteins that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. The cytokeratin proteins play a critical role in differentiation, as well as tissue specialization and function, to maintain the overall structural integrity of epithelial cells. Cytokeratins are also useful markers in identifying the origin of metastatic tumors. Cytokeratin 16 is expressed in benign stratified squamous epithelium and squamous cell carcinoma of the head and neck, as well as luminal cells of mammary gland and sweat ducts. It is absent in noninvasive breast carcinomas and normal breast tissue. Mutations in the Cytokeratin 16 gene cause various diseases, including pachyonychia congenita type 1 (PC1), nonepidermolytic palmoplantar keratoderma (NEPPK) and unilateral palmoplantar verrucous nevus (UPVN).

Alternative Name:
CK-16, K16, CK 16, CK-16, CK16, Cytokeratin-16, Cytokeratin16, FNEPPK, Focal non epidermolytic palmoplantar keratoderma, K 16, K16, K1C16, K1CP, Keratin 1 type I, Keratin 16, Keratin, Keratin type I cytoskeletal 16, Keratin-16, Keratin16, KRT 16, Krt16, KRT16A, NEPPK, PC1, type I cytoskeletal 16,

Application Dilution:
WB:1:1,000-1:2,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Specificity: Cytokeratin 16 polyclonal antibody detects endogenous levels of Cytokeratin 16 protein.

Immunogen:
recombinant protein

MW: 51 kDa

Swiss-Prot: P08779(Human)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.