Cytokeratin 17 polyclonal, anti-human, rat
€388.00
In stock
SKU
BS6649
Background:
Cytokeratin 17 is a member of the Cytokeratin subfamily of intermediate filament proteins (IFPs). It is unique in that it is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. Cytokeratin 17 contains 432 amino acids and is expressed in the nail bed, hair follicle, sebaceous glands and other epidermal appendages. Cytokeratin 17 functions to regulate cell growth and size through its interactions with the adaptor protein 14-3-3-sigma to mediate protein synthesis. Mutations in the gene encoding for Cytokeratin 17 lead to depressed protein translation and smaller sized skin keratinocytes, corresponding to decreased Akt/mTOR signaling activity. Cytokeratin 17 may be a useful marker for cervical stem cell identification, squamous cell carcinoma of the larynx, respiratory syncytial virus and transitional cell carcinomas of the human urinary tract.
Alternative Name:
Keratin, type I cytoskeletal 17, Cytokeratin-17, Short name=CK-17, CK17, Keratin-17, Short name=K17, KRT17, Keratin17, Cytokeratin17,
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: Cytokeratin 17 polyclonal antibody detects endogenous levels of Cytokeratin 17 protein.
Immunogen:
Recombinant full length Human Cytokeratin 17.
MW: ~ 48 kDa
Swis Prot.: Q04695
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Cytokeratin 17 is a member of the Cytokeratin subfamily of intermediate filament proteins (IFPs). It is unique in that it is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. Cytokeratin 17 contains 432 amino acids and is expressed in the nail bed, hair follicle, sebaceous glands and other epidermal appendages. Cytokeratin 17 functions to regulate cell growth and size through its interactions with the adaptor protein 14-3-3-sigma to mediate protein synthesis. Mutations in the gene encoding for Cytokeratin 17 lead to depressed protein translation and smaller sized skin keratinocytes, corresponding to decreased Akt/mTOR signaling activity. Cytokeratin 17 may be a useful marker for cervical stem cell identification, squamous cell carcinoma of the larynx, respiratory syncytial virus and transitional cell carcinomas of the human urinary tract.
Alternative Name:
Keratin, type I cytoskeletal 17, Cytokeratin-17, Short name=CK-17, CK17, Keratin-17, Short name=K17, KRT17, Keratin17, Cytokeratin17,
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: Cytokeratin 17 polyclonal antibody detects endogenous levels of Cytokeratin 17 protein.
Immunogen:
Recombinant full length Human Cytokeratin 17.
MW: ~ 48 kDa
Swis Prot.: Q04695
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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