Cytokeratin 18 (clone 1B3), anti-human, mouse, rat

Background:
Keratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.Keratin 18 is often used together with keratin 8 and keratin 19 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood.

Synonyms: CK-18, CYK18, K18

Cellular Location: Cytoplasm Nucleus nucleolus perinuclear region

Immunogen:
Recombinant Protein

Gene Symbol: Cytokeratin 18

Gene ID: 3875

Swiss prot: P05783

Calculated MW: 46kDa

Recommended dilution:
WB 1:1000-3000, IF 1:100-200, IHC 1:200-500,

Purity:
Saturated ammonium sulfate precipitation

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.