Cytokeratin 2e polyclonal, anti-human

Background:
The keratin multigene family is made of "soft" epithelial cytokeratins and "hard" hair keratins. While the epithelial cytokeratins are involved in the layering and formation of epithelia, the hair keratins are responsible for creating nails and hair. There are two types of keratins: the acidic class I keratin proteins and the basic/neutral class II keratin proteins. Keratin 2 (KRT2), also known as Keratin type II cytoskeletal 2 epidermal, Keratin-2e (K2e), KRTE, Cytokeratin-2e (CK-2e), KRT2A or KRT2E, is a 639 amino acid class II epithelial Keratin protein belonging to the intermediate filament family. Encoded by a gene that maps to human chromosome 12q13.13, Keratin 2 functions in epidermal keratinocyte activation and proliferation, and plays a part in terminal cornification. Highly expressed in upper epithelial tissues, Keratin 2 forms heterotetramers with two class I Keratins and another class II Keratin. Defects in Keratin 2 have been linked to ichthyosis bullosa of Siemens (IBS), a rare autosomal dominant skin disorder.

Alternative Name:
CK-2e, K2e, KRT2, CK 2e, Cytokeratin-2e, Epithelial keratin-2e, K2e, Keratin type II cytoskeletal 2 epidermal, Keratin-2 epidermis, KRT2, KRT2A, KRT2E, Type-II keratin Kb2,

Application Dilution:
WB:1:1,000
IHC:1:50-1:200

Specificity: Cytokeratin 2e polyclonal antibody detects endogenous levels of Cytokeratin 2e protein.

Immunogen:
recombinant protein

MW: 65 kDa

Swiss-Prot: P35908(Human)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.