Cytokeratin 8 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Cytokeratin 8(CK8), also known as Keratin 8(K8), is a type II keratin. Among the various intermediate filament(IF) proteins, cytokeratin 8(CK8) is especially remarkable as it is produced early in embryogenesis, is the only type-II CK occurring in many simple epithelial cells, and can also be synthesized in certain non-epithelial cells. Cytokeratin 8 mRNA was abundant in fetal small intestine, placenta, pancreas, lung, liver, and kidney. Levels of cytokeratin 8 mRNA in placenta increased slightly during pregnancy. He et al.(2002) presented evidence that K8 is a new cytoplasmic target for JNK in Fas receptor-mediated signaling. The functional significance of this phosphorylation could relate to regulation of JNK signaling and/or regulation of keratin dynamics.

Description:
Rabbit IgG polyclonal antibody for Keratin, type II cytoskeletal 8 (KRT8) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
card2 antibody, Cardiac autoantigen 2 120kD antibody, CK 8 antibody, CK-8 antibody, ck8 antibody, Cyk 8 antibody, cyk8 antibody, CYKER antibody, Cytokeratin 8 antibody, Cytokeratin endo A antibody, Cytokeratin-8 antibody, Cytokeratin8 antibody, DreK8 antibody, EndoA antibody, k0 antibody, k2c8 antibody, K2C8_HUMAN antibody, k8 antibody, Keratin 8 antibody, Keratin type II cytoskeletal 8 antibody, Keratin, type II cytoskeletal 8 antibody, Keratin-8 antibody, Keratin8 antibody, KO antibody, Krt 2.8 antibody, Krt 8 antibody, krt8 antibody, MGC118110 antibody, MGC174782 antibody, MGC53564 antibody, MGC85764 antibody, sb:cb186 antibody, Type-II keratin Kb8 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human Cytokeratin 8(127-145aa QQQKTARSNMDNMFESYIN), different from the related rat and mouse sequences by one amino acid.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human.
Predicted to work with: mouse, rat.

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.