Cytokeratin 9 polyclonal, anti-human, mouse, rat

Background:
Cytokeratins comprise a diverse group of intermediate filament proteins that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratin 9 is an unusually large, type I acidic cytokeratin that differentiates human plantar and palmar epidermal cells. Cytokeratin 9 localizes to the suprabasal layers as well as the upper epidermal layers such as the glandular ridges and interridges. The domains of cytokeratin 9 include a head, an α-helical coiled-coil-forming rod, and a tail, cytokeratin 9 shares significant homology with cytokeratin 10. Mutations in the cytokeratin 9 gene correlate with the development of epidermolytic palmoplantar keratoderma (EPPK), an autosomal dominant inherited skin disorder that is characterized by hyperkeratosis of the skin over the palms and soles.

Alternative Name:
CK-9, K9, KRT9, CK 9, CK-9, Cytokeratin 9, Cytokeratin-9, Cytokeratin9, EPPK, K1C9, K9, Keratin 9, Keratin, Keratin type I cytoskeletal 9, Keratin-9, Keratin9, KRT 9, Krt9, Spermatid Perinuclear Ring Manchette Protein K9, type I cytoskeletal 9,

Application Dilution:
WB:1:500-1:1,000
IHC:1:50-1:200

Specificity: Cytokeratin 9 polyclonal antibody detects endogenous levels of Cytokeratin 9 protein.

Immunogen:
recombinant protein

MW: 62 kDa

Swiss-Prot: P35527(Human) Q6RHW0(Mouse) Q8CIS9(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.