Cytokeratin/Keratin 17 polyclonal, anti-human

Quantity: 25 µl

Background:
This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex.

Synonyms:
PC, K17, PC2, PCHC1

Isotype: Guinea pig Polyclonal (GP CK17.1)

Immunogen:
Recombinant human Keratin 17

Form: Stabilized Serum

Specificity:
Acidic human keratin K17 (Mr 46,000); formerly also designated cytokeratin 17. In the epidermis suprabasal staining is found only in cornifying regions and in the outer root sheath of hair follicles.

Reactivity: human

Applications: Immunohistochemistry on frozen and paraffin sections, Immunoblotting

Working DIlution: 1:100 to 1:200 for immunohistochemistry; 1:50 paraffin sections; 1:5,000 to 1:10,000 for immunoblotting (ECL method)

Storage: 2-8C

References:
- Demirkesen, C. et al. (1995) J. Cutan. Pathol. 22: 518-535
- Moll, R. et al. (1995) In: Aktuelle Aspekte der Tumorimmunologie in der Gynaekologie. W. Zuckschwerdt Verlag
- Jennemann R (2007) J Biol Chem 282: 3083-3094