Cytokeratin/Keratin 18 polyclonal, anti-human, bovine, mouse

Quantity: 25 µl

Background:
KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.

Synonyms:
K18, CYK18

Isotype: Guinea pig Polyclonal (GP CK18.2)

Immunogen:
Human Cytokeratin 18, purified from MCF 7

Form: Stabilized Serum

Specificity:
Acidic human keratin K18 (Mr 45,500; formerly also designated cytokeratin 18. Tumors specifically detected: All adeno-Ca tested, undifferentiated CA, hepatocellular CA, cervix Ca.

Reactivity: human, bovine, mouse

Applications: Immunohistochemistry on frozen and paraffin sections, Immunoblotting

Working DIlution: 1:200 for immunohistochemistry on frozen sections; 1:100 paraffin sections; 1:1,000 for immunoblotting (ECL)

Storage: 2-8C

References:
- Magin TM et al. 1990) Eur J Cell Biol 53: 333-348