Cytokeratin/Keratin 5 polyclonal, anti-human, bovine, mouse

Quantity: 25 µl

Background:
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues.

Synonyms:
KRT5, K5, CK5, DDD, DDD1, EBS2, KRT5A

Isotype: Guinea pig Polyclonal (GP5.2)

Immunogen:
Recombinant human Keratin 5

Form: Stabilized Serum

Specificity:
Basic keratin K5 (Mr 58 000; formerly also designated cytokeratin 5), expressed in basal and first suprabasal layers of epidermis. The antiserum reacts with keratin K5, expressed in the basal cells of the larynx, esophagus, trachea, bladder, prostate, cervix, vagina, breast acini, skin and sweat glands. In several studies the correlation between the expression of keratin K5 in different types of carcinomas (putatively derived from basal epithelial cells) and prognosis has been discussed (see references listed below).

Reactivity: human, bovine, mouse

Applications: Immunohistochemistry on frozen and paraffin sections, Cytological material, Immunoblotting

Working DIlution: 1:100 for immunohistochemistry; 1:50 paraffin sections; 1:5,000 for immunoblotting (ECL method)

Storage: 2-8C

References:
- Demirkesen, C. et al. (1995) J. Cutan. Pathol. 22: 518-535
- Moll, R. et al. (1995) In: Aktuelle Aspekte der Tumorimmunologie in der Gynaekologie. W. Zuckschwerdt Verlag