Cytokeratin/Keratin Pan polyclonal, anti-human, most mammals, including mouse

Quantity: 100 µl

Background:
Cytokeratins are precisely regulated in tissue and little is known about the molecular mechanisms underlying this regulation. However, the expression pattern of cytokeratin 6 is known to be particularly complex. It is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyperproliferative situations.

Isotype: Rabbit Polyclonal

Immunogen:
Human skin

Form: Serum containing 0.1% sodium azide

Specificity:
The antibody gives a positive reaction with all stratified squamous epithelia. Renal cell carcinomas and small anaplastic lung carcinomas may remain negative, when examined in paraffin sections.

Reactivity: human, most mammals, including mouse

Applications: Immunohistochemistry on frozen and paraffin sections (proteolytic treatment with pronase or trypsin required)

Working DIlution: 1:25

Positive Control:
Squamous cell carcinoma, skin, cervix

Storage: 2-8C for immediate use, or at -20C (aliquot)

References:
- Ramaekers F et al. (1985) Virchows Arch (Pathol Anat) 408, 127 - 142