Cytokeratins/Keratins 8/18 polyclonal, anti-human, bovine, rat, mouse, syrian hamster, xenopus laevis, chicken

Quantity: 25 µl

Background:
Keratin, type I cytoskeletal 8 also known as cytokeratin-8 (CK-8) or keratin-8 (K8) is a keratin protein that in human is encoded by the KRT8 gene. It is often paired with keratin 18

Synonyms:
K8, KO, CK8, CK-8, CYK8, K2C8, CARD2, K18, CYK18

Isotype: Guinea Pig Polyclonal (GP11)

Immunogen:
Keratin K8/K18 filaments, reconstituted from purified bovine keratins K8 and K18

Form: Stabilized Serum

Specificity:
Mr 52 500 and 45 500. Keratins K8 and K18 (formerly also designated cytokeratins 8 and 18) of simple type epithelium. Tumors specifically detected: All adeno-Ca tested, undifferentiated CA, hepatocellular CA, cervix Ca.

Reactivity: human, bovine, rat, mouse, Syrian hamster, Xenopus laevis, chicken

Applications: Suitable for Immunohistochemistry on frozen & paraffin sections, Cytological material, Immunoblotting (Western), ELISA

Working DIlution: 1:100 for immunohistochemistry, 1:50 for paraffin-embedded tissue, 1:2000 for Western blotting

Storage: 2-8C

References:
- Ruther, U. et al. (1988) Cell 53: 847-856
- Bader, B.L. et al. (1988) Eur. J. Cell Biol. 47: 300-319
- Franke, W.W. and Moll, R. (1987) Differentiation, 35: 145-163
- Knapp, A.C. and Franke W.W. (1989) Cell 59: 67-79
- Hacker, H.J. et al. (1991) Virchows Arch. B Cell Pathol. 60: 213-223