D-dimer (Detection Ab) (clone D10), anti-human

Background:
-D-dimer is a fibrin degradation product (or FDP), a small protein fragment present in the blood after a blood clot is degraded by fibrinolysis. It is so named because it contains two crosslinked D fragments of the fibrin protein. The D-dimer antigen is a unique marker of fibrin degradation that is formed by the sequential action of 3 enzymes: thrombin, factor XIIIa, and plasmin. Its concentration may be determined by a blood test to help diagnose thrombosis. Since its introduction in the 1990s, it has become an important test performed in patients suspected of thrombotic disorders. While a negative result practically rules out thrombosis, a positive result can indicate thrombosis but does not rule out other potential causes. Its main use, therefore, is to exclude thromboembolic disease where the probability is low. In addition, it is used in the diagnosis of the blood disorder disseminated intravascular coagulation.-

Immunogen:
-Human D-dimer protein.-

Specificity:
-It specifically recognize human D-dimer antigen, and does not cross react with BSA, but has week cross-reactivity withfibrinogen.-

Matched antibody pair: -Capture Ab: D-dimer mAb (clone # C6) or D-dimer mAb (clone # C9), Detection Ab: D-dimer mAb (clone # D10)-

Recommended Application:
-Western Blot, WB; ELISA; Lateral flow-

Product Form: -Liquid-

Purification & Buffer: -Protein A or G purified and supplied in 0.01 M PBS (pH7.4) without preservative.-

Purity: ->95% by HPLC & SDS-PAGE-

Storage Instruction:
-Aliquot and store at -20℃ for long term (at least one year). Avoid repeated freeze and thaw cycles.