Dab1 (phospho-Y232) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS4643
Background:
Dab1, a homolog of the Drosophila Disabled protein, is an adaptor protein involved in neural development. This cytoplasmic protein is tyrosine-phosphorylated during rapid expansion of the developing nervous system, and it is thought to interact with other proteins via a domain similar to the PTB domains of the Shc family. Dab1 has been shown to interact with the SH2 domains of Src, Fyn and Abl. Mutations in Dab1 result in widespread abnormalities in the brain, similar to those seen in Reelin mutants. Reelin is a secreted protein thought to play a role in directing migrating neurons. Evidence suggests that Dab1 functions downstream of Reelin in a signaling pathway involved in positioning cells in the developing brain
Alternative Name:
Disabled homolog 1, DAB1
Application Dilution: WB: 1:500~1:1000
Specificity: p-Dab1 (Y232) polyclonal antibody detects endogenous levels of Dab1 protein when phosphorylated at Tyr232
Immunogen:
Synthetic phosphopeptide derived from human Dab1 around the phosphorylation site of Tyrosine 232.
MW: ~ 60 kDa
Swis Prot.: O75553
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Dab1, a homolog of the Drosophila Disabled protein, is an adaptor protein involved in neural development. This cytoplasmic protein is tyrosine-phosphorylated during rapid expansion of the developing nervous system, and it is thought to interact with other proteins via a domain similar to the PTB domains of the Shc family. Dab1 has been shown to interact with the SH2 domains of Src, Fyn and Abl. Mutations in Dab1 result in widespread abnormalities in the brain, similar to those seen in Reelin mutants. Reelin is a secreted protein thought to play a role in directing migrating neurons. Evidence suggests that Dab1 functions downstream of Reelin in a signaling pathway involved in positioning cells in the developing brain
Alternative Name:
Disabled homolog 1, DAB1
Application Dilution: WB: 1:500~1:1000
Specificity: p-Dab1 (Y232) polyclonal antibody detects endogenous levels of Dab1 protein when phosphorylated at Tyr232
Immunogen:
Synthetic phosphopeptide derived from human Dab1 around the phosphorylation site of Tyrosine 232.
MW: ~ 60 kDa
Swis Prot.: O75553
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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