DAB2 Polyclonal Antibody

Background:
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Signal Transduction

Synonyms:
DAB 2, Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila), DAB2, Differentially expressed in ovarian cancer 2, Differentially expressed protein 2, Disabled (Drosophila) homolog 2 (mitogen responsive phosphoprotein), Disabled homolog 2, Disabled homolog 2 mitogen responsive phosphoprotein (Drosophila), Disabled homolog 2 mitogen responsive phosphoprotein, Disabled, Drosophila, homolog of, 2, DOC 2, DOC2, FLJ26626, Mitogen responsive phosphoprotein

Immunogen: Recombinant protein of human DAB2

Swissprot: P98082
Gene Accession: BC003064

Calculated MW: 82 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.6 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-7828/sc-7832/sc-13982