DAG1 antibody (clone 2A3), anti-human
€435.00
In stock
SKU
AC-AT1710a
Catalog Number: AC-AT1710a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, E
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, E
Request Information AC-AT1710a">Request Information
Background:
Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.
Other Names:
Dystroglycan, Dystrophin-associated glycoprotein 1, Alpha-dystroglycan, Alpha-DG, Beta-dystroglycan, Beta-DG, DAG1
Antigen Type:
Recombinant Protein
Gene Name: DAG1 (HGNC:2666)
Gene ID: 1605
NCBI Accession: NP_001159400.2;NP_001171105.1;NP_001171106.1;NP_001171107.1;NP_001171108.1;NP_001171109.1;NP_001171110.1;NP_001171111.1;NP_001171112.1;NP_001171113.1;NP_001171114.1;NP_001171115.1;NP_004384.4
Primary Accession: Q14118
Other Accession: BC012740
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.
Other Names:
Dystroglycan, Dystrophin-associated glycoprotein 1, Alpha-dystroglycan, Alpha-DG, Beta-dystroglycan, Beta-DG, DAG1
Antigen Type:
Recombinant Protein
Gene Name: DAG1 (HGNC:2666)
Gene ID: 1605
NCBI Accession: NP_001159400.2;NP_001171105.1;NP_001171106.1;NP_001171107.1;NP_001171108.1;NP_001171109.1;NP_001171110.1;NP_001171111.1;NP_001171112.1;NP_001171113.1;NP_001171114.1;NP_001171115.1;NP_004384.4
Primary Accession: Q14118
Other Accession: BC012740
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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