DANRE park7 polyclonal (C-term), anti-zebrafish

Background:
Protects cells against oxidative stress and cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May function as a redox-sensitive chaperone (By similarity). Protects dopaminergic neurons against cell death arising from oxidative stress and proteasome inhibition, probably by a TP53/p53-dependent mechanism.

Other Names:
Protein DJ-1, zDJ-1, 34--, Parkinson disease protein 7 homolog, park7 {ECO:0000312|EMBL:AAH834751}

Target/Specificity:
This DANRE park7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-149 amino acids from the C-terminal region of DANRE park7.

Antigen Region:
120-149

Antigen Type: Synthetic Peptide

Gene Name: park7 {ECO:0000312|EMBL:AAH83475.1}
Gene ID: 449674
Primary Accession: Q5XJ36
NCBI Accession: NP_001005938.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.