DAP12 polyclonal, anti-human antibody
€310.00
In stock
SKU
AC-ABV11003-100
Catalog Number: AC-ABV11003-100
Size: 100 µg
Host: Rabbit IgG
Applications: WB
Datasheet
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Size: 100 µg
Host: Rabbit IgG
Applications: WB
Datasheet
Request Information
Background:
DAP12 (KARAP) is a natural killer (NK) cell-expressed cell surface receptor and belongs to the immunoglobulin and C-type lectin superfamily. Unlike other members of this family which possess immunoreceptor tyrosine-based inhibitory motifs (ITIM), DAP12 contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and is present as a disulphide-bonded homodimer. Crosslinking of DAP 12-KIR complexes (membrane glycoproteins of the killer-cell inhibitory receptor family without an ITIM in their cytoplasmic domain) results in cellular activation.
Other Names:
DAP-12, DAP 12, DAP12, TYRO protein tyrosine kinase binding protein , TYROBP
Primary Accession: O54885
Gene Name: Tyrobp {ECO:0000312|MGI:MGI:1277211}
Gene ID: 22177
Concentration (mg/ml): 0.5 mg/ml
DAP12 (KARAP) is a natural killer (NK) cell-expressed cell surface receptor and belongs to the immunoglobulin and C-type lectin superfamily. Unlike other members of this family which possess immunoreceptor tyrosine-based inhibitory motifs (ITIM), DAP12 contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and is present as a disulphide-bonded homodimer. Crosslinking of DAP 12-KIR complexes (membrane glycoproteins of the killer-cell inhibitory receptor family without an ITIM in their cytoplasmic domain) results in cellular activation.
Other Names:
DAP-12, DAP 12, DAP12, TYRO protein tyrosine kinase binding protein , TYROBP
Primary Accession: O54885
Gene Name: Tyrobp {ECO:0000312|MGI:MGI:1277211}
Gene ID: 22177
Concentration (mg/ml): 0.5 mg/ml
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