Daxx polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
DAXX(death-domain associated protein) also known as DAP6(Death-associated protein 6) or BING2, was first discovered through its cytoplasmic interaction with the classical death receptor Fas. Human DAXX encodes a 740-amino acid polypeptide containing a nuclear localization signal. Functional analyses by Yang et al.(1997) demonstrated that Daxx binds to the Fas death domain and enhances Fas-mediated apoptosis. The authors suggested that DAXX and FADD define 2 distinct apoptotic pathways downstream of Fas. The DAXX gene is mapped to human chromosome 6p21.3 by somatic cell hybrid panels and fluorescence in situ hybridization, a region containing the HLA and putative autoimmune disease genes. MSP58 overexpression relieved DAXX-mediated transcriptional repression. Immunoprecipitation and Western blot analysis with DAXX mutants showed that the N terminus of DAXX interacts with the C terminus of DMAP. Transient expression of DAXX or DMAP1 caused repression of glucocorticoid receptor-mediated transcription.

Description:
Rabbit IgG polyclonal antibody for Death domain-associated protein 6 (DAXX) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
antibody, BING 2 antibody, BING2 antibody, CENP-C binding protein antibody, DAP 6 antibody, DAP6 antibody, Daxx antibody, DAXX antibody, DAXX_HUMAN antibody, Death associated protein 6 antibody, Death domain associated protein 6 antibody, Death domain associated protein antibody, Death domain-associated protein 6 antibody, EAP 1 antibody, EAP1 antibody, ETS1 associated protein 1 antibody, ETS1-associated protein 1 antibody, Fas binding protein antibody, Fas death domain associated protein antibody, Fas death domain-associated protein antibody, hDaxx antibody, MGC126245 antibody, MGC126246 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence in the middle region of human Daxx(325-341aa QERRHLDLIYNFGCHLT), identical to the related mouse and rat sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human.
Predicted to work with: mouse, rat.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.