DCC Polyclonal Antibody

Background:
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.

Research Area: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Neuroscience

Synonyms:
Colorectal cancer related chromosome sequence 18, Colorectal cancer suppressor, CRC 18, CRC18, CRCR 1, CRCR1, DCC, DCC, Deleted in colorectal cancer protein, Deleted in colorectal carcinoma, Immunoglobulin superfamily DCC subclass member 1, Netrin receptor DCC, Tumor suppressor protein DCC

Immunogen: Synthetic peptide of human DCC

Swissprot: P43146
Gene Accession: NP_005206

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.7 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-6534/sc-6535/sc-11437