DCC polyclonal (Center), anti-mouse
€0.00
In stock
SKU
AC-AP12334c
Catalog Number: AC-AP12334c
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB32203
Applications: IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB32203
Applications: IHC-P, WB
Datasheet
Request Information
Background:
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
Other Names:
Netrin receptor DCC, Colorectal cancer suppressor, Immunoglobulin superfamily DCC subclass member 1, Tumor suppressor protein DCC, DCC, IGDCC1
Target/Specificity:
This DCC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 643-670 amino acids from the Central region of human DCC.
Antigen Region:
643-670
Antigen Type: Synthetic Peptide
Gene Name: DCC
Gene ID: 1630
Primary Accession: P43146
NCBI Accession: NP_005206.2
Other Accession: Q63155; P70211; NP_005206.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
Other Names:
Netrin receptor DCC, Colorectal cancer suppressor, Immunoglobulin superfamily DCC subclass member 1, Tumor suppressor protein DCC, DCC, IGDCC1
Target/Specificity:
This DCC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 643-670 amino acids from the Central region of human DCC.
Antigen Region:
643-670
Antigen Type: Synthetic Peptide
Gene Name: DCC
Gene ID: 1630
Primary Accession: P43146
NCBI Accession: NP_005206.2
Other Accession: Q63155; P70211; NP_005206.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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