DCTN3 Polyclonal Antibody

Background:
This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants.

Research Area: Cancer, Cell Biology, Signal Transduction

Synonyms:
DCNT22, DCTN 22, DCTN22, Dctn3, DCTN3, dynactin 3 (p22), dynactin 3, dynactin 3 isoform 1, Dynactin complex subunit 22 kDa subunit, dynactin light chain, Dynactin subunit 3, p22

Immunogen: Recombinant protein of human DCTN3

Swissprot: O75935
Gene Accession: BC000319

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.6 mg/mL
Dilution: IHC 1:100-1:300

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-162754/sc-162755